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Quatrième de couverture : "Nous vivons actuellement un profond bouleversement des stratégies thérapeutiques en cancérologie, comme en témoigne le prix Nobel de médecine 2018 attribué à James P. Allison et Tasuku Honjo pour leurs travaux sur le traitement du cancer par "inhibition de la régulation immunitaire négative". Les découvertes récentes en immunologie et la preuve de leur pertinence clinique conduisent à repenser la maladie cancéreuse, jusqu'à sa définition même. Le présent peut être vu en cancérologie comme un moment charnière entre une période où la cancérologie s'est centrée sur la tumeur et une période qui s'ouvre, recentrée sur l'hôte. L'objectif de cet ouvrage est de faire le point sur les différents acteurs de la réponse immunitaire, de revenir aux "fondamentaux", afin de comprendre les mécanismes engagés par les différentes immunothérapies, pourquoi ces thérapies sont efficaces, mais aussi potentiellement toxiques. Cet ouvrage a pour ambition d'éclairer la relation hôte-tumeur et le fonctionnement du système immunitaire face au cancer, mais également de donner les clefs pour comprendre les nouvelles approches (CAR-T, enzymes immunosuppressives, etc.) qui sont en cours de développement thérapeutique et, pour certaines d'entre elles, déjà au stade des essais cliniques. Rédigé par des équipes de référence impliquées dans la recherche fondamentale et appliquée en immunologie des tumeurs, ce livre correspond à une actualité et à un besoin. Il intéressera particulièrement chercheurs et personnels soignants en oncologie et immunologie."
Neoplastic Stem Cells --- Antibodies, Neoplasm --- Immunotherapy --- Neoplasms --- Cancer Vaccines --- Biomarkers, Tumor --- Cancer --- Vaccins anticancéreux --- Marqueurs tumoraux --- therapy --- Immunothérapie --- Thérapeutique --- Cellules cancéreuses. --- Cellules souches. --- Immunothérapie. --- Biologie. --- Immunothérapie. --- Anticorps antitumoraux. --- Cancer cells --- Immune response --- Carcinogenesis --- Cellules cancéreuses. --- Immunological aspects. --- immunology --- Vaccins anticancéreux. --- Marqueurs tumoraux. --- Thérapeutique. --- Antibodies, Neoplasm. --- Immunothérapie anticancéreuse. --- Biomarkers, Tumor. --- therapy.
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It all started with an observation. Edward Jenner, an English physician, observed that milkmaids who contracted cowpox were rarely victims of smallpox epidemic, a disease that in?icted a heavy toll on humankind with an estimate of 500 million victimsworldwide.In1796,Jennerinoculatedtheextracted?uidfromblistersonthe handofamilkmaidwhowasinfectedwithcowpoxintothearman8yearoldpeasant boy. After the boy recovered from a mild illness caused by this inoculation, Jenner exposed him to smallpox and to his delight the boy did not develop the disease. He published his work in 1798 in three publications titled “Vaccination Against smallpox”, where the term vaccination is derived from the Latin word “vacca” meaning cow. Jenner was recognized to be the father of modern immunology, and hisworkmarkedthecommencementofanewdawninmedicinethatledtothe1979 declaration by the World Health Organization (WHO) of the global eradication of smallpox. By the beginning of the 20th century, vaccines for typhoid fever, rabies, polio, plaque and diphtherias were in use, and nowadays we are equipped with effectivevaccinesagainstmorethan20infectiousdiseasessuchasmeningitis,rubella, whooping cough, rabies, and hepatitis B among others.
Cancer Vaccines. --- Neoplasms --- Antigens, Neoplasm. --- Tumors --- Cancer vaccines. --- Tumeurs --- Vaccins anticancéreux --- immunology. --- Immunological aspects. --- Immunologie --- Tumors - Immunological aspects. --- Cancer vaccines --- Cancer Vaccines --- Antigens, Neoplasm --- Diseases --- Antigens --- Vaccines --- Biological Products --- Biological Factors --- Complex Mixtures --- Chemicals and Drugs --- Oncology --- Microbiology & Immunology --- Medicine --- Biology --- Health & Biological Sciences --- Immunological aspects --- Oncologic vaccines --- Oncology vaccines --- Neoplasm vaccines --- Tumor vaccines --- Tumor immunology --- Medicine. --- Oncology. --- Medicine & Public Health. --- Oncology .
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Papillomaviridae --- Papillomavirus Vaccines --- National Health Programs --- Papillomavirus --- Vaccins contre les papillomavirus --- Programmes nationaux de santé --- Health Program, National --- Health Programs, National --- National Health Program --- Program, National Health --- Programs, National Health --- Programme national de santé --- National Health Insurance --- Health Insurance, National --- Insurance, National Health --- National Health Insurance, Non-U.S. --- National Health Insurance, Non U.S. --- Health Services, National --- Health Service, National --- National Health Service --- Service, National Health --- Services, National Health --- National Health Services --- Assurance maladie nationale --- Assurance santé nationale --- Assurance maladie nationale non américaine --- Assurance santé nationale non américaine --- Services de santé nationaux --- Service de santé national --- Programmes gouvernementaux --- Vaccines, Papillomavirus --- Vaccins anti-papillomavirus --- Vaccins antipapillomavirus --- Human Papillomavirus Vaccines --- Papillomavirus Vaccines, Human --- Vaccines, Human Papillomavirus --- Human Papilloma Virus Vaccines --- HPV Vaccines --- Vaccins contre les papillomavirus humains --- Vaccins anti-PVH --- Vaccins anti-papillomavirus humains --- Vaccins antipapillomavirus humains --- Vaccins anticancéreux --- Papillomaviridés --- Infections à Papillomavirus --- Papillomavirus humains --- Alphapapillomavirus --- Virus à ADN bicaténaire --- Government Programs --- HPV Vaccine --- Human Papilloma Virus Vaccine --- Human Papillomavirus Vaccine --- Papillomavirus Vaccine --- Papillomavirus Vaccine, Human --- Vaccine, HPV --- Vaccine, Human Papillomavirus --- Vaccine, Papillomavirus --- HPV, Human Papillomavirus Viruses --- Human Papilloma Virus --- Human Papillomavirus Viruses --- Human Papilloma Viruses --- Human Papillomavirus Virus --- Papilloma Virus, Human --- Papilloma Viruses, Human --- Papillomavirus Virus, Human --- Papillomavirus Viruses, Human --- Virus, Human Papilloma --- Virus, Human Papillomavirus --- Viruses, Human Papilloma --- Viruses, Human Papillomavirus
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